Haplotypic and Genotypic Association of Catechol-O-Methyltransferase rs4680 and rs4818 Polymorphisms and Treatment Resistance in Schizophrenia

• Main Authors: Marina Sagud (Author), Lucija Tudor (Author), Suzana Uzun (Author), Matea Nikolac Perkovic (Author), Maja Zivkovic (Author), Marcela Konjevod (Author), Oliver Kozumplik (Author), Bjanka Vuksan Cusa (Author), Dubravka Svob Strac (Author), Iva Rados (Author), Ninoslav Mimica (Author), Alma Mihaljevic Peles (Author), Gordana Nedic Erjavec (Author), Nela Pivac (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Treatment-resistant schizophrenia (TRS) continues to be a challenge. It was related to different factors, including alterations in the activity of brain dopaminergic system, which could be influenced by the dopamine-degrading enzyme, catechol-O-methyltransferase (COMT). Variants of the COMT gene hav...