Haplotypic and Genotypic Association of Catechol-O-Methyltransferase rs4680 and rs4818 Polymorphisms and Treatment Resistance in Schizophrenia

• मुख्य लेखकों: Marina Sagud (लेखक), Lucija Tudor (लेखक), Suzana Uzun (लेखक), Matea Nikolac Perkovic (लेखक), Maja Zivkovic (लेखक), Marcela Konjevod (लेखक), Oliver Kozumplik (लेखक), Bjanka Vuksan Cusa (लेखक), Dubravka Svob Strac (लेखक), Iva Rados (लेखक), Ninoslav Mimica (लेखक), Alma Mihaljevic Peles (लेखक), Gordana Nedic Erjavec (लेखक), Nela Pivac (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2018-07-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Treatment-resistant schizophrenia (TRS) continues to be a challenge. It was related to different factors, including alterations in the activity of brain dopaminergic system, which could be influenced by the dopamine-degrading enzyme, catechol-O-methyltransferase (COMT). Variants of the COMT gene hav...