Assessment of the role of afucosylated glycoforms on the in vitro antibody-dependent phagocytosis activity of an antibody to Aβ aggregates

• Auteurs principaux: Allyson Kwiatkowski (Auteur), Carl Co (Auteur), Sei Kameoka (Auteur), An Zhang (Auteur), John Coughlin (Auteur), Tom Cameron (Auteur), Eric Chiao (Auteur), Svetlana Bergelson (Auteur), Cullen Schmid Mason (Auteur)
• Format: Livre
• Publié: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

The terminal sugars of Fc glycans can influence the Fc-dependent biological activities of monoclonal antibody therapeutics. Afucosylated N-glycans have been shown to significantly alter binding to FcγRIIIa and affect antibody-dependent cell-mediated cytotoxicity (ADCC). Therefore, in order to mainta...