Assessment of the role of afucosylated glycoforms on the in vitro antibody-dependent phagocytosis activity of an antibody to Aβ aggregates

• मुख्य लेखकों: Allyson Kwiatkowski (लेखक), Carl Co (लेखक), Sei Kameoka (लेखक), An Zhang (लेखक), John Coughlin (लेखक), Tom Cameron (लेखक), Eric Chiao (लेखक), Svetlana Bergelson (लेखक), Cullen Schmid Mason (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The terminal sugars of Fc glycans can influence the Fc-dependent biological activities of monoclonal antibody therapeutics. Afucosylated N-glycans have been shown to significantly alter binding to FcγRIIIa and affect antibody-dependent cell-mediated cytotoxicity (ADCC). Therefore, in order to mainta...