Assessment of the role of afucosylated glycoforms on the in vitro antibody-dependent phagocytosis activity of an antibody to Aβ aggregates

• Main Authors: Allyson Kwiatkowski (Author), Carl Co (Author), Sei Kameoka (Author), An Zhang (Author), John Coughlin (Author), Tom Cameron (Author), Eric Chiao (Author), Svetlana Bergelson (Author), Cullen Schmid Mason (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The terminal sugars of Fc glycans can influence the Fc-dependent biological activities of monoclonal antibody therapeutics. Afucosylated N-glycans have been shown to significantly alter binding to FcγRIIIa and affect antibody-dependent cell-mediated cytotoxicity (ADCC). Therefore, in order to mainta...