Artemisinin derivative DHA27 enhances the antibacterial effect of aminoglycosides against Pseudomonas aeruginosa by inhibiting mRNA expression of aminoglycoside-modifying enzymes

• Hauptverfasser: Nuoyan Wang (Verfasst von), Xuemin Chen (Verfasst von), Jing Luo (Verfasst von), Fei Deng (Verfasst von), Fuguo Shi (Verfasst von), Qin Wu (Verfasst von), Yasi Huang (Verfasst von), Qin Ouyang (Verfasst von), Rongxin Qin (Verfasst von), Hong Zhou (Verfasst von)
• Format: Buch
• Veröffentlicht: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Bacterial resistance is becoming increasingly serious, the present study aimed to investigate the mechanism of antibacterial sensitization effect of DHA27 combined with tobramycin in tobramycin-resistant Pseudomonas aeruginosa (PA). We found that DHA27 combined with aminoglycosides had an antibacter...