Artemisinin derivative DHA27 enhances the antibacterial effect of aminoglycosides against Pseudomonas aeruginosa by inhibiting mRNA expression of aminoglycoside-modifying enzymes

• Main Authors: Nuoyan Wang (Author), Xuemin Chen (Author), Jing Luo (Author), Fei Deng (Author), Fuguo Shi (Author), Qin Wu (Author), Yasi Huang (Author), Qin Ouyang (Author), Rongxin Qin (Author), Hong Zhou (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bacterial resistance is becoming increasingly serious, the present study aimed to investigate the mechanism of antibacterial sensitization effect of DHA27 combined with tobramycin in tobramycin-resistant Pseudomonas aeruginosa (PA). We found that DHA27 combined with aminoglycosides had an antibacter...