Novel CD123 polyaptamer hydrogel edited by Cas9/sgRNA for AML-targeted therapy

• Main Authors: Haibin Wu (Author), Liyu Zhang (Author), Zeen Zhu (Author), Chenxi Ding (Author), Shengquan Chen (Author), Ruiping Liu (Author), Huafeng Fan (Author), Yang Chen (Author), Hui Li (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

CD123 targeting molecules have been widely applied in acute myelocytic leukemia (AML) therapeutics. Although antibodies have been more widely used as targeting molecules, aptamer have unique advantages for CD123 targeting therapy. In this study, we constructed an aptamer hydrogel termed as SSFH whic...