A four-protein metabolon assembled by a small peptide protein creates the pentacyclic carbonate ring of aldgamycins

• Main Authors: Qiaozhen Wang (Author), Xiaolong Tang (Author), Ping Dai (Author), Chuanxi Wang (Author), Weiyang Zhang (Author), Guodong Chen (Author), Kui Hong (Author), Dan Hu (Author), Hao Gao (Author), Xinsheng Yao (Author)
• Format: Book
• Published: Elsevier, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Organic carbonates (OCs) are a class of compounds featured by a carbonyl flanked by two alkoxy/aryloxy groups. They exist in either linear or cyclic forms, of which the majority encountered in nature adopt a pentacyclic structure. However, the enzymatic basis for pentacyclic carbonate ring formation...