Role of 5-HT1A-mediated upregulation of brain indoleamine 2,3 dioxygenase 1 in the reduced antidepressant and antihyperalgesic effects of fluoxetine during maintenance treatment

• Main Authors: Jiajia Dai (Author), Hyangin Kim (Author), Zerong You (Author), Michael F. McCabe (Author), Shuzhuo Zhang (Author), Shiyu Wang (Author), Grewo Lim (Author), Lucy Chen (Author), Jianren Mao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The reduced antidepressant and antihyperalgesic effects of selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine during maintenance treatment has been reported, but little is known about the molecular mechanism of this phenomenon. In three comorbid pain and depression animal models (gen...