Selonsertib Alleviates the Progression of Rat Osteoarthritis: An in vitro and in vivo Study

• Main Authors: Jiyuan Yan (Author), Yingchi Zhang (Author), Gaohong Sheng (Author), Bowei Ni (Author), Yifan Xiao (Author), Shanxi Wang (Author), Tianqi Wang (Author), Yongzhuang Ma (Author), Huaixi Wang (Author), Hua Wu (Author), Chang Tu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Osteoarthritis (OA) is a prevalent degenerative joint disease. Its development is highly associated with inflammatory response and apoptosis in chondrocytes. Selonsertib (Ser), the inhibitor of Apoptosis Signal-regulated kinase-1 (ASK1), has exhibited multiple therapeutic effects in several diseases...