CK2 Pro-Survival Role in Prostate Cancer Is Mediated via Maintenance and Promotion of Androgen Receptor and NFκB p65 Expression

• Main Authors: Janeen H. Trembley (Author), Betsy T. Kren (Author), Md. J. Abedin (Author), Daniel P. Shaughnessy (Author), Yingming Li (Author), Scott M. Dehm (Author), Khalil Ahmed (Author)
• 格式: 圖書
• 出版: MDPI AG, 2019-06-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

The prosurvival protein kinase CK2, androgen receptor (AR), and nuclear factor kappa B (NFκB) interact in the function of prostate cells, and there is evidence of crosstalk between these signals in the pathobiology of prostate cancer (PCa). As CK2 is elevated in PCa, and AR and NFκB are involved in...