NMS-873 Leads to Dysfunctional Glycometabolism in A p97-Independent Manner in HCT116 Colon Cancer Cells

• Main Authors: Shan Li (Author), Feng Wang (Author), Gang Zhang (Author), Tsui-Fen Chou (Author)
• 格式: 圖書
• 出版: MDPI AG, 2022-03-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Adenosine triphosphate (ATP)-competitive p97 inhibitor CB-5339, the successor of CB-5083, is being evaluated in Phase 1 clinical trials for anti-cancer therapy. Different modes-of-action p97 inhibitors such as allosteric inhibitors are useful to overcome drug-induced resistance, one of the major pro...