Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases

Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases

Three open-source anti-kinetoplastid chemical boxes derived from a whole-cell phenotypic screening by GlaxoSmithKline (Tres Cantos Anti-Kinetoplastid Screening, TCAKS) were exploited for the discovery of a novel core structure inspiring new treatments of parasitic diseases targeting the trypansosmat...

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Main Authors: Matteo Santucci (Author), Rosaria Luciani (Author), Eleonora Gianquinto (Author), Cecilia Pozzi (Author), Flavio di Pisa (Author), Lucia dello Iacono (Author), Giacomo Landi (Author), Lorenzo Tagliazucchi (Author), Stefano Mangani (Author), Francesca Spyrakis (Author), Maria Paola Costi (Author)
Format: Book
Published: MDPI AG, 2021-11-01T00:00:00Z.
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