Nanosized Liposomes Containing Bile Salt: A Vesicular Nanocarrier for Enhancing Oral Bioavailability of BCS Class III Drug

• Main Authors: Mosab Arafat (Author), Cathrin Kirchhoefer (Author), Momir Mikov (Author), Muhammad Sarfraz (Author), Raimar Löbenberg (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2017-08-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

PURPOSE: Liposomes have been studied as a colloidal carrier in drug delivery systems, especially for oral administration. However, their low structural integrity in the gut is still a major shortcoming. Membrane disruptive effects of physiological bile salts in the small intestine result in prematur...