Loss of Tbk1 kinase activity protects mice from diet-induced metabolic dysfunction

• Main Authors: Victoria H. Cruz (Author), Emily N. Arner (Author), Katherine W. Wynne (Author), Philipp E. Scherer (Author), Rolf A. Brekken (Author)
• Format: Book
• Published: Elsevier, 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: TANK Binding Kinase 1 (TBK1) has been implicated in the regulation of metabolism through studies with the drug amlexanox, an inhibitor of the IκB kinase (IKK)-related kinases. Amlexanox induced weight loss, reduced fatty liver and insulin resistance in high fat diet (HFD) fed mice and has...