Loss of Tbk1 kinase activity protects mice from diet-induced metabolic dysfunction

• Үндсэн зохиолчид: Victoria H. Cruz (Зохиогч), Emily N. Arner (Зохиогч), Katherine W. Wynne (Зохиогч), Philipp E. Scherer (Зохиогч), Rolf A. Brekken (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Elsevier, 2018-10-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Objective: TANK Binding Kinase 1 (TBK1) has been implicated in the regulation of metabolism through studies with the drug amlexanox, an inhibitor of the IκB kinase (IKK)-related kinases. Amlexanox induced weight loss, reduced fatty liver and insulin resistance in high fat diet (HFD) fed mice and has...