Effects of Piperazine Derivative on Paclitaxel Pharmacokinetics

• Main Authors: Jaeok Lee (Author), Song Wha Chae (Author), A Reum Oh (Author), Ji Hye Yoo (Author), Hea-Young Park Choo (Author), Sandy Jeong Rhie (Author), Hwa Jeong Lee (Author)
• Format: Book
• Published: MDPI AG, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Paclitaxel (PTX) is an anticancer agent that is used to treat many cancers but it has a very low oral bioavailability due, at least in part, to the drug efflux transporter, P-glycoprotein (P-gp). Therefore, this study was performed to enhance oral bioavailability of PTX. In this study, we investigat...