Development of an ELISA for the quantification of mycolactone, the cytotoxic macrolide toxin of Mycobacterium ulcerans.

• Main Authors: Louisa Warryn (Author), Jean-Pierre Dangy (Author), Philipp Gersbach (Author), Matthias Gehringer (Author), Anja Schäfer (Author), Marie-Thérèse Ruf (Author), Nicolas Ruggli (Author), Karl-Heinz Altmann (Author), Gerd Pluschke (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mycolactones, macrolide cytotoxins, are key virulence factors of Mycobacterium ulcerans, the etiological agent of the chronic necrotizing skin disease Buruli ulcer. There is urgent need for a simple point-of-care laboratory test for Buruli ulcer and mycolactone represents a promising target for the...