Effects of islatravir (4'-ethynyl-2-fluoro-2'-deoxyadenosine or EFdA) on renal tubular cells and islatravir's interactions with organic anion transporters

• Main Authors: Meika Kaneko (Author), Yoshie Reien (Author), Hanae Morio (Author), Tomoko Fukuuchi (Author), Kiyoko Kaneko (Author), Yuri Hirayama (Author), Hirofumi Hashimoto (Author), Nobuyo Kuwata (Author), Hiroaki Mitsuya (Author), Naohiko Anzai (Author)
• Format: Book
• Published: Elsevier, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Islatravir (ISL; 4'-ethynyl-2-fluoro-2'-deoxyadenosine or EFdA) is a novel reverse transcriptase translocation inhibitor and has a unique structure and high antiviral activity against wild-type and multidrug resistant HIV strains. In this study, we investigated whether islatravir (ISL) can...