Daphnetin ameliorates Aβ pathogenesis via STAT3/GFAP signaling in an APP/PS1 double-transgenic mouse model of Alzheimer's disease

• Main Authors: Peipei Gao (Author), Zhen Wang (Author), Mengyao Lei (Author), Jiaxing Che (Author), Shuangxi Zhang (Author), Tiantian Zhang (Author), Yachong Hu (Author), Le Shi (Author), Li Cui (Author), Jiankang Liu (Author), Mami Noda (Author), Yunhua Peng (Author), Jiangang Long (Author)
• Format: Book
• Published: Elsevier, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alzheimer's disease (AD) has become a major public health problem that affects the elderly population. Therapeutic compounds with curative effects are not available due to the complex pathogenesis of AD. Daphnetin, a natural coumarin derivative and inhibitor of various kinases, has anti-inflamm...