Mosquito CYP4C21 knockout reduces dengue virus and Zika virus replication in Aedes aegypti cells

• Main Authors: Xiaoxue Xie (Author), Di Wang (Author), Bo Li (Author), Manjin Li (Author), Dan Xing (Author), Teng Zhao (Author), Xinyu Zhou (Author), Chunxiao Li (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aedes aegypti (Ae. aegypti) is a major vector of dengue virus (DENV) and Zika virus (ZIKV). Understanding the complex interaction mechanisms between mosquito vectors and arboviruses is essential to interrupt virus transmission. This study constructed CYP4C21 knockout (KO) Aag2 cells (Ae. aegypti cel...