Pathophysiologic and transcriptomic analyses of viscerotropic yellow fever in a rhesus macaque model.

• Main Authors: Flora Engelmann (Author), Laurence Josset (Author), Thomas Girke (Author), Byung Park (Author), Alex Barron (Author), Jesse Dewane (Author), Erika Hammarlund (Author), Anne Lewis (Author), Michael K Axthelm (Author), Mark K Slifka (Author), Ilhem Messaoudi (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Infection with yellow fever virus (YFV), an explosively replicating flavivirus, results in viral hemorrhagic disease characterized by cardiovascular shock and multi-organ failure. Unvaccinated populations experience 20 to 50% fatality. Few studies have examined the pathophysiological changes that oc...