Cloning and functional complementation of ten Schistosoma mansoni phosphodiesterases expressed in the mammalian host stages.

• Main Authors: Jane C Munday (Author), Stefan Kunz (Author), Titilola D Kalejaiye (Author), Marco Siderius (Author), Susanne Schroeder (Author), Daniel Paape (Author), Ali H Alghamdi (Author), Zainab Abbasi (Author), Sheng Xiang Huang (Author), Anne-Marie Donachie (Author), Samia William (Author), Abdel Nasser Sabra (Author), Geert Jan Sterk (Author), Sanaa S Botros (Author), David G Brown (Author), Charles S Hoffman (Author), Rob Leurs (Author), Harry P de Koning (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Only a single drug against schistosomiasis is currently available and new drug development is urgently required but very few drug targets have been validated and characterised. However, regulatory systems including cyclic nucleotide metabolism are emerging as primary candidates for drug discovery. H...