In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis.

• Main Authors: Alexandra Ehrens (Author), Christopher S Lunde (Author), Robert T Jacobs (Author), Dominique Struever (Author), Marianne Koschel (Author), Stefan J Frohberger (Author), Franziska Lenz (Author), Martina Fendler (Author), Joseph D Turner (Author), Stephen A Ward (Author), Mark J Taylor (Author), Yvonne R Freund (Author), Rianna Stefanakis (Author), Eric Easom (Author), Xianfeng Li (Author), Jacob J Plattner (Author), Achim Hoerauf (Author), Marc P Hübner (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The elimination of filarial diseases such as onchocerciasis and lymphatic filariasis is hampered by the lack of a macrofilaricidal-adult worm killing-drug. In the present study, we tested the in vivo efficacy of AN11251, a boron-pleuromutilin that targets endosymbiotic Wolbachia bacteria from filari...