Elucidation of the mechanism of action of ailanthone in the treatment of colorectal cancer: integration of network pharmacology, bioinformatics analysis and experimental validation

• Main Authors: Shanbo Ma (Author), Xiaodi Guo (Author), Ruisi Han (Author), Qian Meng (Author), Yan Zhang (Author), Wei Quan (Author), Shan Miao (Author), Zhao Yang (Author), Xiaopeng Shi (Author), Siwang Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Ailanthone, a small compound derived from the bark of Ailanthus altissima (Mill.) Swingle, has several anti-tumour properties. However, the activity and mechanism of ailanthone in colorectal cancer (CRC) remain to be investigated. This study aims to comprehensively investigate the mechan...