mRNA Encoding a Bispecific Single Domain Antibody Construct Protects against Influenza A Virus Infection in Mice

• Main Authors: Lien Van Hoecke (Author), Rein Verbeke (Author), Dorien De Vlieger (Author), Heleen Dewitte (Author), Kenny Roose (Author), Sharon Van Nevel (Author), Olga Krysko (Author), Claus Bachert (Author), Bert Schepens (Author), Ine Lentacker (Author), Xavier Saelens (Author)
• Format: Book
• Published: Elsevier, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To date, mRNA-based biologics have mainly been developed for prophylactic and therapeutic vaccination to combat infectious diseases or cancer. In the past years, optimization of the characteristics of in vitro transcribed mRNA has led to significant reduction of the inflammatory responses. Thanks to...