Searching for drug leads targeted to the hydrophobic cleft of dengue virus capsid protein

• Main Authors: Liliane O. Ortlieb (Author), Ícaro P. Caruso (Author), Nathane C. Mebus-Antunes (Author), Andrea T. Da Poian (Author), Elaine da C. Petronilho (Author), José Daniel Figueroa-Villar (Author), Claudia J. Nascimento (Author), Fabio C. L. Almeida (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We synthesised and screened 18 aromatic derivatives of guanylhydrazones and oximes aromatic for their capacity to bind to dengue virus capsid protein (DENVC). The intended therapeutic target was the hydrophobic cleft of DENVC, which is a region responsible for its anchoring in lipid droplets in the...