Novel Antioxidant Therapy with the Immediate Precursor to Glutathione, γ-Glutamylcysteine (GGC), Ameliorates LPS-Induced Cellular Stress in In Vitro 3D-Differentiated Airway Model from Primary Cystic Fibrosis Human Bronchial Cells

• Main Authors: Chris K. Hewson (Author), Alexander Capraro (Author), Sharon L. Wong (Author), Elvis Pandzic (Author), Ling Zhong (Author), Bentotage S. M. Fernando (Author), Nikhil T. Awatade (Author), Gene Hart-Smith (Author), Renee M. Whan (Author), Shane R. Thomas (Author), Adam Jaffe (Author), Wallace J. Bridge (Author), Shafagh A. Waters (Author)
• Format: Book
• Published: MDPI AG, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Systemic glutathione deficiency, inflammation, and oxidative stress are hallmarks of cystic fibrosis (CF), an inherited disease that causes persistent lung infections and severe damage to the respiratory system and many of the body organs. Improvements to current antioxidant therapeutic strategies a...