Osthole/borneol thermosensitive gel via intranasal administration enhances intracerebral bioavailability to improve cognitive impairment in APP/PS1 transgenic mice

• Main Authors: Fanchang Wu (Author), Mingjun Huang (Author), Xue Zuo (Author), Ruiye Xie (Author), Jinman Liu (Author), Junyu Ke (Author), Weirong Li (Author), Qi Wang (Author), Yong Liang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alzheimer's disease (AD) poses a significant threat to the global elderly population. Traditional Chinese medicine (TCM) has been widely utilized in the treatment of AD. Osthole, a bioactive ingredient classified as an "emperor" in many TCM formulas, has been demonstrated to effective...