Construction of acetyl-CoA and DBAT hybrid metabolic pathway for acetylation of 10-deacetylbaccatin III to baccatin III

• Những tác giả chính: Hao Wang (Tác giả), Bo-Yong Zhang (Tác giả), Ting Gong (Tác giả), Tian-Jiao Chen (Tác giả), Jing-Jing Chen (Tác giả), Jin-Ling Yang (Tác giả), Ping Zhu (Tác giả)
• Định dạng: Sách
• Được phát hành: Elsevier, 2021-10-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

10-Deacetylbaccatin III (10-DAB) C10 acetylation is an indispensable procedure for Taxol semi-synthesis, which often requires harsh conditions. 10-Deacetylbaccatin III-10-β-O-acetyltransferase (DBAT) catalyzes the acetylation but acetyl-CoA supply remains a key limiting factor. Here we refactored th...