A structure-based approach towards the identification of novel antichagasic compounds: Trypanosoma cruzi carbonic anhydrase inhibitors

• Main Authors: Manuel A. Llanos (Author), María L. Sbaraglini (Author), María L. Villalba (Author), María D. Ruiz (Author), Carolina Carrillo (Author), Catalina Alba Soto (Author), Alan Talevi (Author), Andrea Angeli (Author), Seppo Parkkila (Author), Claudiu T. Supuran (Author), Luciana Gavernet (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Trypanosoma cruzi carbonic anhydrase (TcCA) has recently emerged as an interesting target for the design of new compounds to treat Chagas disease. In this study we report the results of a structure-based virtual screening campaign to identify novel and selective TcCA inhibitors. The combination of p...