Effects of a recombinant humanized anti‐cocaine monoclonal antibody on the metabolism and distribution of cocaine in vitro and in mice

• المؤلفون الرئيسيون: Mackenzie E. Turner (مؤلف), Hanna N. Wetzel (مؤلف), Dakota B. Zinani (مؤلف), Christopher A. Crutchfield (مؤلف), Andrew B. Norman (مؤلف)
• التنسيق: كتاب
• منشور في: Wiley, 2022-10-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Abstract The anti‐cocaine monoclonal antibody, h2E2, is a candidate for treating cocaine‐use disorder. h2E2 binds to and sequesters cocaine in the plasma compartment, effectively decreasing cocaine concentrations in the brains of rats and mice. Despite the binding of cocaine to h2E2, plasma cocaine...