Design, synthesis, and biological evaluation of (thio)urea derivatives as potent Escherichia coli β-glucuronidase inhibitors

• Main Authors: Keren Xu (Author), Leyi Ying (Author), Titi Ying (Author), Qihao Wu (Author), Lin Du (Author), Yanlei Yu (Author), Youmin Ying (Author), Bin Wei (Author), Hong Wang (Author), Zhikun Yang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

EcGUS has drawn considerable attention for its role as a target in alleviating serious GIAEs. In this study, a series of 72 (thio)urea derivatives were designed, synthesised, and biologically assayed. The bioassay results revealed that E-9 (IC50 = 2.68 μM) exhibited a promising inhibitory effect on...