Design, synthesis, and biological evaluation of (thio)urea derivatives as potent Escherichia coli β-glucuronidase inhibitors

• Hoofdauteurs: Keren Xu (Auteur), Leyi Ying (Auteur), Titi Ying (Auteur), Qihao Wu (Auteur), Lin Du (Auteur), Yanlei Yu (Auteur), Youmin Ying (Auteur), Bin Wei (Auteur), Hong Wang (Auteur), Zhikun Yang (Auteur)
• Formaat: Boek
• Gepubliceerd in: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

EcGUS has drawn considerable attention for its role as a target in alleviating serious GIAEs. In this study, a series of 72 (thio)urea derivatives were designed, synthesised, and biologically assayed. The bioassay results revealed that E-9 (IC50 = 2.68 μM) exhibited a promising inhibitory effect on...