Atogepant Is Not Associated With Clinically Meaningful Alanine Aminotransferase Elevations in Healthy Adults

• Main Authors: K. Chris Min (Author), Walter K. Kraft (Author), Phung Bondiskey (Author), Francheska Colón‐González (Author), Wen Liu (Author), Jialin Xu (Author), Deborah Panebianco (Author), Lori Mixson (Author), Marissa F. Dockendorf (Author), Catherine Z. Matthews (Author), Ramesh Boinpally (Author)
• Format: Book
• Published: Wiley, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Atogepant is a potent, selective, oral calcitonin gene-related peptide (CGRP) receptor antagonist in development for migraine prevention. The chemical structure of atogepant is distinct from previous CGRP receptor antagonists, which were associated with elevated serum alanine aminotransferase (ALT)...