Synthesis, characterization, and pharmacological evaluation of some metal complexes of quercetin as P-gp inhibitors

• Main Authors: Kirankumar Shastrala (Author), Sirisha Kalam (Author), Kumaraswamy Damerakonda (Author), Sharvana Bhava Bandaru Sheshagiri (Author), Hitesh Kumar (Author), Ramu Guda (Author), Mamatha Kasula (Author), Satish Kumar Bedada (Author)
• Format: Book
• Published: SpringerOpen, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Six different metal complexes of quercetin (Cu, Zn, Co, Vd, Mo, Ni) were synthesized, purified, and characterized by their physical and spectral (UV, IR) data. They were evaluated for their P-gp (permeability glycoprotein) inhibitory activity by in vitro everted sac method in rat...