Design, synthesis, molecular modeling and biological evaluation of novel Benzoxazole-Benzamide conjugates via a 2-Thioacetamido linker as potential anti-proliferative agents, VEGFR-2 inhibitors and apoptotic inducers

• Main Authors: Ibrahim H. Eissa (Author), Radwan El-Haggar (Author), Mohammed A. Dahab (Author), Marwa F. Ahmed (Author), Hazem A. Mahdy (Author), Reem I. Alsantali (Author), Alaa Elwan (Author), Nicolas Masurier (Author), Samar S. Fatahala (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A novel series of 2-thioacetamide linked benzoxazole-benzamide conjugates 1-15 was designed as potential inhibitors of the vascular endothelial growth factor receptor-2 (VEGFR-2). The prepared compounds were evaluated for their potential antitumor activity and their corresponding selective cytotoxic...