Ruxolitinib, a JAK1/2 Inhibitor, Ameliorates Cytokine Storm in Experimental Models of Hyperinflammation Syndrome

• Main Authors: Eduardo Huarte (Author), Michael T. Peel (Author), Katherine Verbist (Author), Brittany L. Fay (Author), Rachel Bassett (Author), Sabrin Albeituni (Author), Kim E. Nichols (Author), Paul A. Smith (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hyperinflammatory syndromes comprise a heterogeneous group of disorders characterized by severe inflammation, multiple organ dysfunction, and potentially death. In response to antigenic stimulus (e.g., SARS-CoV-2 infection), overactivated CD8+ T-cells and macrophages produce high levels of proinflam...