A study on the preparation conditions of lidocaine microemulsion based on multi-objective genetic algorithm

• Main Authors: Yuchao Qiao (Author), Xuchun Wang (Author), Hao Ren (Author), Yu Cui (Author), Jiahui Ren (Author), Chongqi Hao (Author), Zhiyang Zhao (Author), Jing Liu (Author), Ruiqing Zhao (Author), Yiting Li (Author), Qingping Tian (Author), Lixia Qiu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Topical lidocaine microemulsion preparations with low toxicity, low irritation, strong transdermal capability and convenient administration are urgently needed.Methods: Box-Behnken design was performed for three preparation conditions of 5% lidocaine microemulsions: mass ratio of the mas...