Physiological implications of biased signaling at histamine H2 receptors.

• Main Authors: Natalia eAlonso (Author), Carlos Daniel Zappia (Author), Maia eCabrera (Author), Carlos Alberto Davio (Author), Carina eShayo (Author), Federico eMonczor (Author), Natalia Cristina Fernandez (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Histamine mediates numerous functions acting through its four receptor subtypes all belonging to the large family of seven transmembrane G-protein coupled receptors (GPCRs). In particular, histamine H2 receptor (H2R) is mainly involved in gastric acid production, becoming a classic pharmacological t...