Dual targeting of l-carnitine-conjugated nanoparticles to OCTN2 and ATB0,+ to deliver chemotherapeutic agents for colon cancer therapy

Dual targeting of l-carnitine-conjugated nanoparticles to OCTN2 and ATB0,+ to deliver chemotherapeutic agents for colon cancer therapy

l-Carnitine, obligatory for oxidation of fatty acids, is transported into cells by the Na+-coupled transporter OCTN2 and the Na+/Cl--coupled transporter ATB0,+. Here we investigated the potential of L-carnitine-conjugated poly(lactic-co-glycolic acid) (PLGA) nanoparticles (LC-PLGA NPs) to deliver ch...

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Main Authors: Longfa Kou (Author), Qing Yao (Author), Sathish Sivaprakasam (Author), Qiuhua Luo (Author), Yinghua Sun (Author), Qiang Fu (Author), Zhonggui He (Author), Jin Sun (Author), Vadivel Ganapathy (Author)
Format: Book
Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
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