Involvement of endoplasmic reticulum stress in rifampicin-induced liver injury

• Ngā kaituhi matua: Wanqing Hou (Author), Bernard Nsengimana (Author), Chuyun Yan (Author), Bjorn Nashan (Author), Shuxin Han (Author)
• Hōputu: Pukapuka
• I whakaputaina: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Rifampicin is a first-line antituberculosis drug. Hepatocyte toxicity caused by rifampicin is a significant clinical problem. However, the specific mechanism by which rifampicin causes liver injury is still poorly understood. Endoplasmic reticulum (ER) stress can have both protective and proapoptoti...