Polyporus Polysaccharide Ameliorates Bleomycin-Induced Pulmonary Fibrosis by Suppressing Myofibroblast Differentiation via TGF-β/Smad2/3 Pathway

• Main Authors: Jintao Jiang (Author), Fang Wang (Author), Aishu Luo (Author), Shiyu Lin (Author), Xiaoke Feng (Author), Wei Yan (Author), Yumeng Shi (Author), Qian Zhang (Author), Xin Gu (Author), Guoliang Cui (Author), Jianan Wang (Author), Lei Wang (Author), Qiande Zhang (Author), Wenfeng Tan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pulmonary fibrosis is a major cause of morbidity and mortality in systemic sclerosis (SSc) with no effective medication. Polyporus polysaccharide (PPS), extracted from Chinese herbs, has immune regulation, anticancer, antioxidant and antiinflammatory activities. This study aims to investigate antifi...