Metformin reduces 12-month change in body weight among people newly commenced on clozapine: a retrospective naturalistic cohort study

• Main Authors: Jessica Spokes (Author), Samantha Hollingworth (Author), Karl Winckel (Author), Steve Kisely (Author), Andrea Baker (Author), Peter Cosgrove (Author), Dan Siskind (Author)
• Format: Book
• Published: SAGE Publishing, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: People with schizophrenia have a 15-20-year reduction in life expectancy, driven in part by the metabolic effects of antipsychotics. Clozapine is associated with the highest rates of weight gain. As clozapine remains the most effective antipsychotic for treatment-resistant schizophrenia...