Next-Generation Heterocyclic Electrophiles as Small-Molecule Covalent MurA Inhibitors

• Main Authors: Péter Ábrányi-Balogh (Author), Aaron Keeley (Author), György G. Ferenczy (Author), László Petri (Author), Tímea Imre (Author), Katarina Grabrijan (Author), Martina Hrast (Author), Damijan Knez (Author), Janez Ilaš (Author), Stanislav Gobec (Author), György M. Keserű (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Heterocyclic electrophiles as small covalent fragments showed promising inhibitory activity on the antibacterial target MurA (UDP-N-acetylglucosamine 1-carboxyvinyltransferase, EC:2.5.1.7). Here, we report the second generation of heterocyclic electrophiles: the quaternized analogue of the heterocyc...