Next-Generation Heterocyclic Electrophiles as Small-Molecule Covalent MurA Inhibitors

Next-Generation Heterocyclic Electrophiles as Small-Molecule Covalent MurA Inhibitors

Heterocyclic electrophiles as small covalent fragments showed promising inhibitory activity on the antibacterial target MurA (UDP-N-acetylglucosamine 1-carboxyvinyltransferase, EC:2.5.1.7). Here, we report the second generation of heterocyclic electrophiles: the quaternized analogue of the heterocyc...

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Main Authors: Péter Ábrányi-Balogh (Author), Aaron Keeley (Author), György G. Ferenczy (Author), László Petri (Author), Tímea Imre (Author), Katarina Grabrijan (Author), Martina Hrast (Author), Damijan Knez (Author), Janez Ilaš (Author), Stanislav Gobec (Author), György M. Keserű (Author)
Format: Book
Published: MDPI AG, 2022-11-01T00:00:00Z.
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