Silencing c-Myc Enhances the Antitumor Activity of Bufalin by Suppressing the HIF-1α/SDF-1/CXCR4 Pathway in Pancreatic Cancer Cells

• Main Authors: Xia Liu (Author), Yayun Zhou (Author), Jiamin Peng (Author), Bei Xie (Author), Qiyang Shou (Author), Jianchao Wang (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2020-04-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

BackgroundPancreatic cancer is one of the most aggressive malignancies. Bufalin, a traditional Chinese medicine, has been used to treat pancreatic cancer as an antitumor agent although the mechanism by which it exerts its effects is still unclear. c-Myc has been found to be overexpressed in more tha...