Footprint of positive selection in Treponema pallidum subsp. pallidum genome sequences suggests adaptive microevolution of the syphilis pathogen.

• Main Authors: Lorenzo Giacani (Author), Sujay Chattopadhyay (Author), Arturo Centurion-Lara (Author), Brendan M Jeffrey (Author), Hoavan T Le (Author), Barbara J Molini (Author), Sheila A Lukehart (Author), Evgeni V Sokurenko (Author), Daniel D Rockey (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the rabbit model of syphilis, infection phenotypes associated with the Nichols and Chicago strains of Treponema pallidum (T. pallidum), though similar, are not identical. Between these strains, significant differences are found in expression of, and antibody responses to some candidate virulence...