A Chymase Inhibitory RNA Aptamer Improves Cardiac Function and Survival after Myocardial Infarction

• Main Authors: Denan Jin (Author), Shinji Takai (Author), Yosuke Nonaka (Author), Satoko Yamazaki (Author), Masatoshi Fujiwara (Author), Yoshikazu Nakamura (Author)
• Format: Book
• Published: Elsevier, 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We have reported that mast cell chymase, an angiotensin II-generating enzyme, is important in cardiovascular tissues. Recently, we developed a new chymase-specific inhibitory RNA aptamer, HA28, and we evaluated the effects of HA28 on cardiac function and the mortality rate after myocardial infarctio...