Pharmacological antagonism of the incretin system protects against diet-induced obesity

• Principais autores: Berit Svendsen (Autor), Megan E. Capozzi (Autor), Jingjing Nui (Autor), Sarah A. Hannou (Autor), Brian Finan (Autor), Jacqueline Naylor (Autor), Peter Ravn (Autor), David A. D'Alessio (Autor), Jonathan E. Campbell (Autor)
• Formato: Livro
• Publicado em: Elsevier, 2020-02-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Objective: Glucose-dependent insulinotropic polypeptide is an intestinally derived hormone that is essential for normal metabolic regulation. Loss of the GIP receptor (GIPR) through genetic elimination or pharmacological antagonism reduces body weight and adiposity in the context of nutrient excess....