Dihydrofolate reductase-like protein inactivates hemiaminal pharmacophore for self-resistance in safracin biosynthesis

• मुख्य लेखकों: Ning Shao (लेखक), Xueyang Ma (लेखक), Ying-Ying Zhang (लेखक), Donghui Yang (लेखक), Ming Ma (लेखक), Gong-Li Tang (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2023-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Dihydrofolate reductase (DHFR), a housekeeping enzyme in primary metabolism, has been extensively studied as a model of acid-base catalysis and a clinic drug target. Herein, we investigated the enzymology of a DHFR-like protein SacH in safracin (SAC) biosynthesis, which reductively inactivates hemia...