Dihydrofolate reductase-like protein inactivates hemiaminal pharmacophore for self-resistance in safracin biosynthesis
Dihydrofolate reductase (DHFR), a housekeeping enzyme in primary metabolism, has been extensively studied as a model of acid-base catalysis and a clinic drug target. Herein, we investigated the enzymology of a DHFR-like protein SacH in safracin (SAC) biosynthesis, which reductively inactivates hemia...
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| Main Authors: | , , , , , |
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| Format: | Book |
| Published: |
Elsevier,
2023-03-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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