LC-MS/MS based-comparative study of (S)-nicotine metabolism by microorganisms, mushroom and plant cultures: Parallels to its mammalian metabolic fate

• Main Authors: Amira R. Khattab (Author), Abdel-Rahim S. Ibrahim (Author), Souzan M. Ibrahim (Author), Kamillia A. Abou El-Seoud (Author), Wafaa E. Soliman (Author), Fathy K. El-Fiky (Author)
• Format: Book
• Published: Faculty of Pharmacy, Cairo University, 2015-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The metabolic fate of nicotine using the cell cultures of microorganisms, mushroom and plants was explored using LC-MS/MS analysis. The study demonstrated parallels to phase I mammalian metabolism of nicotine and reported that nicotine was biotransformed into its N-oxide by Streptomyces fradiae cult...