Immune response of rats vaccinated orally with various plant-expressed recombinant cysteine proteinase constructs when challenged with Fasciola hepatica metacercariae.

• Main Authors: Malgorzata Kesik-Brodacka (Author), Agnieszka Lipiec (Author), Monika Kozak Ljunggren (Author), Luiza Jedlina (Author), Katarzyna Miedzinska (Author), Magdalena Mikolajczak (Author), Andrzej Plucienniczak (Author), Andrzej B Legocki (Author), Halina Wedrychowicz (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Cysteine proteinases of Fasciola hepatica are important candidates for vaccine antigens because of their role in fluke biology and host-parasite relationships. In our previous experiments, we found that a recombinant cysteine proteinase cloned from adult F. hepatica (CPFhW) can protect ra...