Study of chronic toxicity of the GB-115 drug formulation
The results of the study of chronic toxicity of the drug formulation of anxiolytic GB-115 are presented. The novel dipeptide in the form of a tablet mass was administered daily orally for 6 months to outbred rats and rabbits of the chinchilla breed at a dose of 1 mg/kg corresponding to the therapeut...
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| Main Authors: | , , , , , |
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| Format: | Book |
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LLC "Publisher OKI",
2020-04-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_df4e3a7673394b2fb23c766a1c7ab3d0 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a A. V. Sorokina |e author |
| 700 | 1 | 0 | |a S. V. Alekseeva |e author |
| 700 | 1 | 0 | |a I. A. Miroshkina |e author |
| 700 | 1 | 0 | |a V. V. Zabrodina |e author |
| 700 | 1 | 0 | |a L. G. Kolik |e author |
| 700 | 1 | 0 | |a A. D. Durnev |e author |
| 245 | 0 | 0 | |a Study of chronic toxicity of the GB-115 drug formulation |
| 260 | |b LLC "Publisher OKI", |c 2020-04-01T00:00:00Z. | ||
| 500 | |a 2587-7836 | ||
| 500 | |a 2686-8830 | ||
| 500 | |a 10.37489/2587-7836-2019-4-37-44 | ||
| 520 | |a The results of the study of chronic toxicity of the drug formulation of anxiolytic GB-115 are presented. The novel dipeptide in the form of a tablet mass was administered daily orally for 6 months to outbred rats and rabbits of the chinchilla breed at a dose of 1 mg/kg corresponding to the therapeutic and 50 mg/kg exceeding the therapeutic dose by 50 times. Clinical, laboratory and pathohistological studies performed in accordance with the General Protocol demonstrated the absence of toxic effects of the GB-115 drug formulation. The exception was the reversible changes in the coagulation activity in rats and rabbits, which were not associated with the dose of the GB-115 solid dosage from. | ||
| 546 | |a RU | ||
| 690 | |a gb-115 | ||
| 690 | |a solid dosage form (tablets) | ||
| 690 | |a chronic toxicity | ||
| 690 | |a rats | ||
| 690 | |a rabbits | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Фармакокинетика и Фармакодинамика, Vol 0, Iss 4, Pp 37-44 (2020) | |
| 787 | 0 | |n https://www.pharmacokinetica.ru/jour/article/view/230 | |
| 787 | 0 | |n https://doaj.org/toc/2587-7836 | |
| 787 | 0 | |n https://doaj.org/toc/2686-8830 | |
| 856 | 4 | 1 | |u https://doaj.org/article/df4e3a7673394b2fb23c766a1c7ab3d0 |z Connect to this object online. |