Chlojaponilactone B Attenuates THP-1 Macrophage Pyroptosis by Inhibiting the TLR/MyD88/NF-κB Pathway

• Main Authors: Qiyin Wen (Author), Bingjinfeng Zhan (Author), Lu Jin (Author), Zijing Peng (Author), Ju Liu (Author), Longping Zhu (Author), Depo Yang (Author), Xinjun Xu (Author), Lixia Zhang (Author), Ge Li (Author), Zhimin Zhao (Author)
• Format: Book
• Published: MDPI AG, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pyroptosis, an innate immune response, plays a crucial role in the pathological process of inflammatory diseases. Although pyroptosis blockade is considered a potential therapeutic strategy, no ideal candidate drug has been identified. The natural product Chojaponilactone B (CJB) has demonstrated an...